Schrader, Charlotte:
ISBN 9783862472413

Curcumin, genistein and allyl isothiocyanate as potential inducers of paraoxonase-1. Studies in cultured hepatocytes and laboratory rodents. Schriftenreihe des Insituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Universität zu Kiel Bd. 61 # Pb., 250 S., 31 Abb.


SCHLAGWORTE:
Paraoxonale-1
Kardiovaskuläre Erkrankungen
Sekundäre Pflanzenstoffe

Paraoxonase-1 (PON1) is an enzyme which is mainly synthesized in the liver. PON1 circulates in the blood bound to HDL and delays and prevents the oxidation of LDL. A high PON1 status may be associated with a reduced cardiovasular disease risk. Beside genetic and life style factors PON1 status may also be determined by dietary and pharmacological factors. Dietary modulators of PON1 status comprise fat and fatty acids, antioxidant vitamins, polyphenols and polyphenol-rich foods. The aim of the present thesis was to answer the question whether curcumin, genistein and isothiocyanantes, yet not described as modulators of PON1 status, may induce PON1 in cultured cells in vitro and laboratory rodents in vivo.

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