Jofre Monseny, Laia:
ISBN 9783899596236

The role of apolipoprotein E genotype on oxidant/antioxidant status and inflammation. Studies in cultured macrophages and targeted replacement mice. Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Universität Kiel Bd. 39


SCHLAGWORTE:
Oxidativer Stress
Entzündung
Apolipoprotein E
Atherosklerose
Makrophagen

Jofre-Monseny 9783899596236.DOC



Cardiovascular disease (CVD) is the leading cause mortality worldwide, with latest statistics suggesting that it is responsible for 17.5 million deaths annually. Among the three common isoforms of apolipoprotein E (apoE), apoE4 is associated with a higher (40-50%) risk of CVD. However, the molecular basis of the apoE4-CVD associations remains unclear. ApoE is mainly secreted in the liver, but also by macrophages at the site of the atherosclerotic plaque, where it is thought to exert antiatherogenic functions independently of its role in lipid metabolism. There is evidence indicating that apoE exhibits antioxidant and immunomodulatory properties in a genotype dependent manner. In order to gain a more comprehensive understanding of the effects of apoE genotype in the pathogenesis of atherosclerosis, the impact of apoE genotype on oxidative stress and inflammation was examined in macrophages in vitro and in targeted replacement mice in vivo.


Laia Jofre Monseny studied pharmacy at the University of Barcelona (Spain) and completed a MSc in Nutrition and Food Science at the University of Reading (UK) in 2003. She did her doctorate studies at the Institute of Human Nutrition and Food Science at the University of Kiel, obtaining her PhD in the field of oxidative stress and cardiovascular disease in 2007.

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