Atom Transfer Radical Polymerization using Initiator-Modified Peptides: Synthesis and Characterization of Novel Bioactive and Shape-Defined Soft Materials. Oberflächenchemie und -physik von Mikrosystemen Bd. 5 # Pb., Großformat (24x17), 196 S., 102 Abb., davon 15 in Farbe, 5 Tab.
peptide-polymer hybrid material
This volume describes the preparation of shape-defined and/or bioactive peptide-polymer hybrid materials, using sequence-defined, initiator-modified peptides, and grafting synthetic polymers directly from the peptide by atom transfer radical polymerization (ATRP).
In one example, a bioactive peptide sequence, which is known to promote the matrix-adhesion of living cells, is conjugated to a synthetic polymer, which is known to prevent cell-adhesion in thin film configuration. This interesting combination of two very contrary properties in a single molecule was further utilized to design surfaces that spatially control the attachment and growth of living cells (i.e. design of novel cell-chips) on solid substrates. In a second part of the thesis, a cyclic D-alt-L-peptide was modified in situ with synthetic polymeric arms. So-prepared coil-ring-coil peptide polymers show an interesting self-assembly into core-shell like nano-rods, where the core consists of stacked peptide rings that are hold together by multiple weak interactions (H-bonds), and the shell consists of terminally attached macromolecules.
In conclusion, this thesis shows that it is possible to in situ prepare a novel class of molecules, i.e. peptide-polymer conjugates, where the peptide can either implement a distinct bioactive property into synthetic polymers, or where a the peptide can act as a structure-guiding module to organize the overall structure of bottom-up designed supramolecular polymers.
Sidar Loschonsky studied pharmacy at the University of Ege in Turkey, where she received her M.Sc. at the Institute for Pharmaceutical Technology. She joined the group of Dr. M. Biesalski (Department of Microsystems Engineering, Division of Prof. Dr. Jürgen Rühe), and in 2007 she received a PhD from the School of Applied Sciences, at the University of Freiburg, Germany.